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Geclosporin

Product Name
Geclosporin
CAS No.
74436-00-3
Chemical Name
Geclosporin
Synonyms
CS-2592;Geclosporin;cyclosporin G;Cyclosporine G;Cyclosporin G (9CI);Cyclosporin Impurity G;Cyclosporine Impurity G;Cyclosporine Impurity 7;Ring spore fungus element;Cyclosporin A, 7-L-norvaline-
CBNumber
CB91117216
Molecular Formula
C63H113N11O12
Formula Weight
1216.64
MOL File
74436-00-3.mol
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Geclosporin Property

Melting point:
196-197°
alpha 
D20 -245° (c = 1.0 in chloroform); D20 -191° (c = 1.04 in methanol)
Boiling point:
1297.8±65.0 °C(Predicted)
Density 
1.013±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
13.32±0.70(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChI
InChI=1/C63H113N11O12/c1-25-27-29-41(15)53(76)52-57(80)66-44(28-26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27,35-48,50-53,76H,26,28-34H2,1-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b27-25+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/s3
InChIKey
ZMKGDQSIRSGUDJ-LIAWPGETNA-N
SMILES
[C@@]1([H])([C@H](O)[C@H](C)C/C=C/C)C(=O)N[C@@H](CCC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C |&1:0,2,4,13,26,34,42,50,55,61,70,79,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C990143
Product name
CyclosporinG
Packaging
5mg
Price
$570
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0011154
Product name
CYCLOSPORIN G
Purity
95.00%
Packaging
5MG
Price
$501.6
Updated
2021/12/16
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Geclosporin Chemical Properties,Usage,Production

Uses

Cylclosporin G is a derivative of Cyclosporin A, an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Uses

Cylclosporin G is a derivative of Cyclosporin A (C989900), an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Geclosporin Preparation Products And Raw materials

Raw materials

Preparation Products

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74436-00-3, GeclosporinRelated Search:


  • Cyclosporine Impurity G
  • Cyclosporin Impurity G
  • CS-2592
  • Cyclosporine G/Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
  • Cyclosporine G
  • Geclosporin
  • (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
  • Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl)
  • Cyclosporin A, 7-L-norvaline-
  • cyclosporin G
  • Ring spore fungus element
  • Cyclosporin Impurity 7(Cyclosporin G)
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
  • Cyclosporine Impurity 7
  • Cyclosporin G (9CI)
  • 74436-00-3
  • C63H113N11O12